Bcs Class 1 Drugs
Bcs classification system. 1.
BIOPHARMACEUTICS CLASSIFICATION SYSTEM. Contents. Introduction.
Overview of the Classification system. Applications. Conclusion. References.
Introduction ۞Biopharmaceutics Classification System (BCS)♥ Scientific framework for classifying drug substances based on their aqueous solubility and intestinal permeability What is the need for a classification based on biopharmaceutics of the drug? Its importance in determining bioavailability. ORAL ROUTE♠ Route of choice for the formulators Continues to dominate the area of drug delivery technologies. LIMITATIONS Absorption and Bioavailability in the milieu of gastrointestinal tract. Limitations more prominent with the advent of protein and peptide drugs compounds emerging as a result of combinatorial chemistry and the technique of high throughput screening.
API structure salt form and excipients Bioavailability of drug is determined byextent of drug solubility and permeability drug solubility drug product quality attributes. Biopharmaceutics Classification System Guidance provided by the U.S. Food and Drug Administration for predicting the intestinal drug absorption The fundamental basis established by Dr. Gordon Amidon Distinguished Science Award (Aug ’06,FIP) First introduced into regulatory decision-making process in the guidance document on Immediate Release Solid Oral Dosage Forms: Scale Up And Post Approval Changes.
Bcs Class 2 Drugs List
Eterlogic virtual serial port emulator pc. Drug development tool that allows estimation of the contributions of 3 major factors, that affect oral drug absorption from immediate release solid oral dosage forms Dissolution Solubility Intestinal permeability.
Ne 47 caffeine citrate Cafcit 1,3 48 calcitriol Rocaltrol 2,4 49 candesartan cilexetil Atacand 2 50 captopril Capoten 3 51 carbamazepine Tegretol 2 52 carbidopa/levodopa Sinemet 1/3 53 carisoprodol Soma 2/4 54 cefaclor Ceclor 3 55 cefadroxil Duricef 3 56 cefdinir Omnicef 4 57 cefixime Suprax (Discontinued) 4 58 cefprozil Cefzil 3 59 ceftibuten Cedax? 60 cefuroxime axetil Ceftin 4 61 celecoxib Celebrex 2 62 cephalexin Keflex 4 63 cetirizine HCl Zyrtec 1,3 64 cetirizine/pseudoephedrine Cetiri-D 1/3 65 chlorhexidine Peridex? 66 chloroquine phosphate Aralen 1 67 chlorothiazide Diuril 4 68 chlorpheniramine/hydrocodone Tussionex 1/?
69 ciprofloxacin HCl Cipro 3 70 ciprofloxacin/dexamethasone Ciprodex 3/1,3 71 clarithromycin Biaxin 4 72 clindamycin Cleocin 1 73 clobetasol Temovate? 74 clonazepam Klonopin? 75 clonidine hcl Catapres 1 (LogP), 3 (CLogP) 76 clopidogrel bisulfate Plavix 2 77 clorazepate dipotassium Tranxene? 78 clotrimazole/betamethasone Lotrisone 2/2 79 codeine phosphate Tylenol w/Codeine 3 80 codeine phosphate/guaifenesin Mytussin AC 3/? 81 colchicine Colcrys 3 82 colesevelam HCl Welchol? 83 cortisone acetate Cortone? 84 cyclobenzaprine Amrix 1 85 cyclophosphamide Cytoxan 1,3 86 cyclosporine Neoral/Sandimmune 2,3,4 87 dantrolene Dantrium?
Bcs Class 2 Drug
88 dapsone Daspone 4,2 89 desloratadine Clarinex 1 90 desmopressin Desmopressin? 91 desogestrel/ethinyl estradiol Mircette?/1 92 dexamethasone Decadron 1 (CLogP), 3 (LogP) 93 dexmethylphenidate Focalin?
94 dexmethylphenidate Focalin XR? 95 diazepam Valium 1 96 diazoxide Proglycem?